If a lesion is both red and white, which part should be biopsied?

• A. Only the red portion
• B. Only the white portion
• C. Both the red and white portions
• D. Neither of the portions

Answer: (C)

When a lesion presents with both red and white components, it's essential to biopsy both areas to obtain a comprehensive understanding of the pathology involved. The red parts of a lesion may indicate areas of inflammation, vascular activity, or other processes, while the white parts can signify keratinization, fibrosis, or other changes. By sampling both portions, the biopsy captures a broader spectrum of the lesion's characteristics, allowing for a more accurate diagnosis.

Biopsying only one portion could lead to an incomplete picture and potentially miss critical aspects of the condition. In cases where lesions are heterogeneous, such as those with areas of both red and white, examining them together is crucial for differential diagnosis and for determining the appropriate treatment plan. Thus, to achieve the best diagnostic outcome, it is important to biopsy both the red and white sections of the lesion.