Select a symptom that is NOT related to sickle cell anemia?

• A. Acute chest syndrome
• B. Decreased white blood cell count
• C. Increased susceptibility to infections
• D. Jaundice

Answer: (B)

The symptom that is not related to sickle cell anemia is a decreased white blood cell count. In fact, sickle cell anemia is associated with an increased risk of infections rather than a decrease in the white blood cells, particularly due to the dysfunction of the spleen. Patients with sickle cell anemia often experience increased susceptibility to infections, especially from encapsulated bacteria, because the sickled cells can lead to splenic dysfunction and asplenia over time.

The other symptoms listed are directly related to the pathophysiology of sickle cell anemia. Acute chest syndrome, for example, is a serious complication characterized by chest pain, fever, and respiratory symptoms, resulting from blockage of blood flow in the lungs due to sickled cells. Jaundice occurs due to the increased breakdown of red blood cells, leading to elevated bilirubin levels. Thus, the relationship between the other symptoms and sickle cell anemia is well-established, while a decreased white blood cell count does not align with the expected hematological effects of this condition.