What is the recommended dosage of amoxicillin for antibiotic prophylaxis in a patient without a penicillin allergy?

• A. 1g
• B. 2g
• C. 500mg
• D. 3g

Answer: (B)

The recommended dosage of amoxicillin for antibiotic prophylaxis in a patient without a penicillin allergy is 2 grams. This dosage is specifically established for the prevention of infective endocarditis in patients undergoing certain dental or surgical procedures that have a high risk of causing bacteremia. The 2-gram dosage is intended to provide adequate levels of the antibiotic in the bloodstream to effectively prevent infection.

The other choices do not meet the established guidelines for appropriate prophylactic dosing. The lower dosages, such as 1 gram or 500 mg, are insufficient to adequately prevent the risk of infection during high-risk procedures. The 3-gram dose exceeds the recommended amount and could potentially lead to increased side effects without providing additional benefits for prophylaxis. Thus, the 2-gram dosage aligns with the recommendations provided in clinical guidelines for this specific use case.